As the vessels become old, their branches loose their structure and become much more tortuous, resulting in thickening of the walls. The thickening of the arterial wall pointed out the difference between the vessels in the young and in the old. Thirdly, his concept of nutrition, added a final touch to his description of the process. Secondly, the study of anatomy delineated his observations on the effects of age on anatomical structures, particularly on blood vessels. Firstly, his study of hydrodynamics paved the way to bring to light various factors governing the flow of fluid. His investigations of atherosclerosis are no exception, which present a clear-cut description by combining three separate fields of research.
His scientific work is most remarkable in his multilateral approach to the problem. Leonardo da Vinci’s description of atherosclerosis is well known. Leonardo da Vinci was a famous Italian artist, inventor and scientist born in Italy in 1452 and died in France in 1519 at the age of 67.
In conclusion: this was the real Code of Leonardo da Vinci. They established that the cellular uptake of low-density lipoprotein (LDL) essentially requires the LDL receptor. On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s. The FH code of Leonardo da Vinci was given immense consideration by scientists like Carl Muller, who described the xanthomas tuberosum and angina pectoris. This is probably the first case of familial hypercholesterolemia (FH). A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the inner end of the left upper eyelid and a soft bumpy well-defined swelling of the dorsum of the right hand beneath the index finger about 3 cm long.
In 1506, he finished his masterpiece, painting of Mona Lisa. His investigations of atherosclerosis judiciously combine three separate fields of research. Among the researchers and scientists, he is favourably known for his remarkable efforts in scientific work.
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